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Clots and vaccines | Ferniglab Weblog


Clots and vaccines

Blood clots, for instance, deep vein thromboses or pulmonary embolisms, are severe and we must always rightly be involved about these. With ~ 17 M doses of the AZ vaccine delivered into individuals, we have now studies of 15 instances of deep vein thrombosis and 22 instances of pulmonary embolism. Deep vein thrombosis happens at fee of 0.1% (so 1 in 1000) throughout all age teams, growing with age. So every single day meaning round 47 instances in a inhabitants of 17 million – in truth will probably be extra, as a result of these vaccinated will not be consultant of the inhabitants, however an older section.

If we take into account that vaccination has been occurring at a excessive fee for a little bit over 2 months, then we count on a minimum of 2,800 instances of deep vein thrombosis.

We are able to draw some restricted conclusions concerning clots, the AZ and different vaccines.

  1. The reporting mechanism could also be very, very poor, and solely a fraction of affected person outcomes are reported. That is in stark distinction to a scientific trial, the place ALL outcomes re reported – recall that one poor particular person on the Pfizer/BioNT trial was killed by a lightening strike, and within the AZ trial there have been 2 deaths within the vaccination group and 4 within the placebo group. These and different deaths had been unrelated to the vaccine.

Selective reporting results in fantasy.

  1. Reporting isn’t so poor, so the correlation is that vaccination protects in opposition to thrombosis. With out realizing the standard of reporting of hostile results and the chance {that a} good many clinicians will take into account many circumstances in vaccinated sufferers to be unrelated to the vaccine, this intriguing chance stays a chance and no extra.
  2. “Clot”, a minimum of for UK audio system of English has a second which means, akin to the US ‘blockhead’. It could be that the AZ vaccine prompts clots in authorities.

At current the most definitely causal relation is (3). It’s because we have now ample proof impartial of vaccination programmes that show an typically increased focus of clots in authorities and within the higher reaches of many greasy poles than one would count on had been altitude to correlate not directly with capacity.

Word: H/T @archer_rs who jogged my memory that the one vaccine that’s non-profit is the AZ vaccine. The historical past of medication teaches us that the revenue motive results in hiding actual and severe hostile occasions.

International South Ecosystems are Producing Breakthrough Innovation to Clear up Native Local weather Wants


International locations in lots of components of the world are already experiencing the consequences of local weather change, and International South populations are notably weak. In accordance with UN Commerce and Improvement (UNCTAD), the International South broadly contains Africa, Latin America and the Caribbean, Asia excluding Israel, Japan, and South Korea, and Oceania excluding Australia and New Zealand.

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Warmth waves pose dangers to human well being and meals provide chains, and housing and infrastructure are threatened by droughts, flooding, and storms. These results are forecast to extend over the approaching years. Efficient cleantech innovation ecosystems produce and scale the applied sciences and options we have to gradual local weather change and fight the consequences on weak populations globally, bringing financial advantages within the course of. Rising cleantech ecosystems in low- and middle-income international locations (LIMCs) globally are producing innovation to serve unmet wants of International South markets.

Mitigation is International, Adaptation is Native

Cleantech Group modelled the consequences of local weather change on eight low- and middle-income international locations throughout 4 continents throughout totally different local weather situations. Within the robust mitigation situation, the international locations confronted decrease danger of local weather hazards. Türkiye was one of many international locations. The chart under reveals how Istanbul’s danger of heatwaves will increase from low to medium within the excessive emissions situation, and water stress will increase from medium to excessive.

Adaptation applied sciences have gotten more and more crucial nonetheless mitigation continues to be important. The international locations experiencing the worst results of local weather change are usually not all the time the most important emitters, due to this fact continued mitigation efforts rely upon international collaboration.

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Local weather hazards impression a number of sectors, together with dangers to human habitat, well being, vitality, water and meals provide chains. Australia’s agricultural sector is grappling with opposed results on crops from each flooding and drought, relying on the season. Heatwaves have been linked to increased cases of coronary heart assaults, in addition to heat-related diseases equivalent to heatstroke. Outcomes like lack of infrastructure will scale back entry to healthcare and sanitation, and crop failure results in lack of earnings for farmers. Around the globe, electrical energy grids are in danger from excessive climate occasions together with hurricanes, wildfires and heatwaves.

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Throughout industries, innovators are creating options to reply to these challenges.

  • Netherlands-based innovator Desolenator has developed a decentralized, solar-powered water desalination system, contributing to drought resilience.
  • German startup Dryad is engaged on an early warning system for forest fires.
  • Singaporean Amperesand makes transformers which decrease the impression of utmost climate on electrical energy grids.

Adopting local weather readiness options equivalent to these will result in long-term GDP enhancements, powered by averted losses.

 

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Constructing a Begin-up Solves One Downside: Constructing an Ecosystem Solves Many Issues

Deploying local weather adaptation and resilience options helps keep away from losses and related detrimental GDP impression. Producing, scaling, and exporting these options results in financial progress in addition to constructive local weather impression. Place-based cleantech ecosystems produce and scale a gentle stream of start-ups who work to mitigate or sort out the consequences of local weather change. Cleantech ecosystems and clusters might develop out of established innovation facilities, or legacy industries which have to decarbonize, or round metropolis and regional challenges, together with local weather change results.

Ecosystems are formed by strategic priorities and native assets. For instance, the South African authorities has recognized a possibility to develop ex-coal mining areas into cleantech innovation hubs; within the face of accelerating water stress, Morocco is directing assets into supporting home-grown water applied sciences. Spain is constructing on its present automotive trade to drive the most important electromobility cluster in Southern Europe.

 Local weather change results are transferring quick up the checklist of strategic priorities, with international locations from India to Chile innovating their method out of meals safety dangers.

  • EF Polymer, based in Rajasthan, produces a polymer which helps crops to retain water, decreasing irrigation wants and soil degradation.
  • PolyNatural, from Chile, reduces meals waste via a pure meals coating which extends shelf life.

Improvements equivalent to these, which have functions in lots of international locations, have the potential to scale globally, amplifying local weather and social impression in addition to financial progress.

Efficient cleantech ecosystems and clusters present the connective tissue for systemic innovation, turning particular person successes into a gentle stream of innovation, and supporting that innovation to market via funding, enterprise help, and connection to clients and international networks. This types a “virtuous circle” of constructive financial progress, leading to elevated funding and extra jobs. Analysis by the European Fee discovered that start-ups situated inside clusters (native, sector-thematic ecosystems) develop 20% quicker than the market common.

That is vital as a result of native ecosystems produce innovation which is tailor-made to native wants and constraints. These could also be low-cost variations of options which have been profitable in different geographies, however they could even be personalized in response to native market wants.

  • Kenyan innovator Roam has developed EV two-wheelers that are sturdier than their Chinese language counterparts, as a result of native entrepreneurs want them to shift heavy hundreds.

Powered by improvements like this one, Africa’s electrical two and three-wheeler market is rising quickly.

 

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Across the globe, mission-driven entrepreneurs are producing thrilling improvements to unravel tomorrow’s issues. Cleantech ecosystems catalyze innovation at velocity and scale. Deliberately strengthening rising cleantech ecosystems to construct on their distinctive strengths and alternatives can create a ripple impact and quickly enhance the quantity of innovation they carry to market, with exceptional local weather, social, and financial rewards.

clipped() doesn’t have an effect on hit testing – Ole Begemann


The clipped() modifier in SwiftUI clips a view to its bounds, hiding any out-of-bounds content material. However observe that clipping doesn’t have an effect on hit testing; the clipped view can nonetheless obtain faucets/clicks outdoors the seen space.

I examined this on iOS 16.1 and macOS 13.0.

Instance

Right here’s a 300×300 sq., which we then constrain to a 100×100 body. I additionally added a border across the outer body to visualise the views:

Rectangle()
  .fill(.orange.gradient)
  .body(width: 300, peak: 300)
  // Set view to 100×100 → renders out of bounds
  .body(width: 100, peak: 100)
  .border(.blue)

SwiftUI views don’t clip their content material by default, therefore the total 300×300 sq. stays seen. Discover the blue border that signifies the 100×100 outer body:

Now let’s add .clipped() to clip the massive sq. to the 100×100 body. I additionally made the sq. tappable and added a button:

VStack {
  Button("You'll be able to't faucet me!") {
    buttonTapCount += 1
  }
  .buttonStyle(.borderedProminent)

  Rectangle()
    .fill(.orange.gradient)
    .body(width: 300, peak: 300)
    .body(width: 100, peak: 100)
    .clipped()
    .onTapGesture {
      rectTapCount += 1
    }
}

If you run this code, you’ll uncover that the button isn’t tappable in any respect. It’s because the (unclipped) sq., regardless of not being absolutely seen, obscures the button and “steals” all faucets.


Xcode preview displaying a blue button and a small orange square. A larger dashed orange outline covers both the smaller square and the button.
The dashed define signifies the hit space of the orange sq.. The button isn’t tappable as a result of it’s coated by the clipped view with respect to hit testing.

The repair: .contentShape()

The contentShape(_:) modifier defines the hit testing space for a view. By including .contentShape(Rectangle()) to the 100×100 body, we restrict hit testing to that space, making the button tappable once more:

  Rectangle()
    .fill(.orange.gradient)
    .body(width: 300, peak: 300)
    .body(width: 100, peak: 100)
    .contentShape(Rectangle())
    .clipped()

Notice that the order of .contentShape(Rectangle()) and .clipped() could possibly be swapped. The essential factor is that contentShape is an (oblique) mum or dad of the 100×100 body modifier that defines the dimensions of the hit testing space.

Video demo

I made a brief video that demonstrates the impact:

  • Initially, faucets on the button, and even on the encompassing whitespace, register as faucets on the sq..
  • The highest change toggles show of the sq. earlier than clipping. This illustrates its hit testing space.
  • The second change provides .contentShape(Rectangle()) to restrict hit testing to the seen space. Now tapping the button increments the button’s faucet depend.

The complete code for this demo is out there on GitHub.

Abstract

The clipped() modifier doesn’t have an effect on the clipped view’s hit testing area. The identical is true for clipShape(_:). It’s usually a good suggestion to mix these modifiers with .contentShape(Rectangle()) to carry the hit testing logic in sync with the UI.

Microsoft August Patch Tuesday Fastened 10 Zero-Day Vulnerabilities

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The August 2024 Patch Tuesday Replace bundle from Microsoft is large, with 10 zero-day fixes. This month’s safety replace additionally addressed 9 critical-severity vulnerabilities, patching 94 bugs in whole. The severity of the vulnerabilities addressed with August updates makes it essential for all Microsoft customers to patch their programs instantly.

Microsoft Launched 10 Zero-Day Safety Fixes

Essentially the most noteworthy safety patches with August Patch Tuesday from Microsoft handle the next 10 zero-day flaws. Out of those 10, the next 6 vulnerabilities went underneath assault prior public disclosure and patching.

Publicly Exploited Zero-Days

  • CVE-2024-38189 (CVSS 8.8; essential): A distant code execution vulnerability in Microsoft Mission that an adversary might set off by luring the sufferer into opening a maliciously crafted Microsoft Workplace Mission file.
  • CVE-2024-38178 (CVSS 7.5; essential): A reminiscence corruption vulnerability within the Scripting Engine that an unauthenticated attacker might exploit by sending a maliciously crafted URL to the sufferer.
  • CVE-2024-38193 (CVSS 7.8; essential): A privilege escalation vulnerability in Home windows Ancillary Perform Driver for WinSock, permitting SYSTEM privileges to an adversary. Microsoft didn’t share many particulars in regards to the exploitation.
  • CVE-2024-38106 (CVSS 7.0; essential): A privilege escalation flaw in Home windows Kernel that might permit SYSTEM privileges to an adversary upon triggering a race situation.
  • CVE-2024-38107 (CVSS 7.8; essential): A privilege escalation flaw affecting Home windows Energy Dependency Coordinator. Once more, Microsoft didn’t share exact particulars in regards to the exploit moreover disclosing that profitable exploitation of this vulnerability grants SYSTEM privileges to an attacker.
  • CVE-2024-38213 (CVSS 6.5; reasonable): A Home windows Mark of the Internet Safety Characteristic Bypass that permits an adversary to bypass Home windows SmartScreen. Exploiting the flaw requires an adversary to lure the sufferer into opening a maliciously crafted file.

Publicly Disclosed Zero-Days

Whereas not exploited, the remaining 4 vulnerabilities grew to become publicly recognized earlier than Microsoft might repair them. The tech big shared mitigations for these vulnerabilities within the respective advisories.

  • CVE-2024-38200 (CVSS 6.5; essential): A spoofing vulnerability affecting Microsoft Workplace.
  • CVE-2024-38199 (CVSS 9.8; essential): Distant code execution vulnerability within the Home windows Line Printer Daemon (LPD) Service.
  • CVE-2024-21302 (CVSS 6.7; essential): A privilege escalation vulnerability in Home windows Safe Kernel Mode, exploiting which allowed SYSTEM privileges.
  • CVE-2024-38202 (CVSS; essential): A privilege escalation vulnerability in Home windows Replace Stack. This vulnerability, along with CVE-2024-21302, might permit downgrade assaults that unpatch Home windows programs.

Different Necessary Patch Tuesday August 2024 Updates From Microsoft

Alongside the massive variety of zero-day vulnerabilities, Microsoft additionally addressed 9 essential severity vulnerabilities and 74 essential severity points this month. These embody 6 denial of service vulnerabilities, 30 privilege escalation points, 9 info disclosure flaws, 28 distant code execution vulnerabilities, 2 safety function bypass points, 4 spoofing flaws, a single tampering problem, and a pair of cross-site scripting vulnerabilities.

When in comparison with the July Patch Tuesday, which addressed over 140 vulnerabilities, this month’s safety replace bundle seems slightly modest in that it consists of 94 safety fixes. Nevertheless, it’s extra essential for customers because it addresses an enormous variety of zero-day vulnerabilities and significant severity flaws. Due to this fact, all customers should be certain that their programs are up to date as quickly as doable by manually checking for updates as a substitute of ready for the automated updates to reach.

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