Sulfate or Phosphate?
November 24, 2022 by ferniglab
Some months earlier than @robField’s tweet setting off the practice that led to the Eu sensor that discriminates PAP/PAPS, Ed Yates and myself have been having a curry with Dulce Papy-Garcia from UPEC, who had examined considered one of our PhD college students. A matter we mentioned at size was ‘why sulfate’. That’s, why does biology use each sulfate and phosphate to change submit synthesis proteins, polysaccharides and different molecules. We didn’t give you a solution, however the dialog led Ed and myself to contemplate that the query merited exploration.
This we thought can be a easy matter.
It turned out to be one of the tough papers Ed and myself have written, to the extent that after N drafts (the place N is a considerably bigger quantity than both of us had skilled in any earlier writing train) and too many summers we nonetheless had nothing passable. So, we cunningly inveigled two colleagues, Tim Rudd from NIBSC and Marcelo Lima from Keele to hitch us on what we marketed because the sunny seaside of sulfate and phosphate, however which in actuality was a reasonably dank quagmire. There may be although one thing about power in numbers, and with very useful enter from Steve Butler in Loughborough, we arrived at what we thought-about a passable synthesis. Fortunately, the reviewers concurred, and the paper is now printed at Royal Society Interfaces, “Phosphorylation and sulfation share a standard biosynthetic pathway, however lengthen biochemical and evolutionary variety of organic macromolecules in distinct methods”.
That is not at all the final phrase on the matter, however together with some earlier considerate papers we cite (if we’ve got missed one, please let me know) it offers some concepts that will assist us to know why biology co-opted specific parts from the inorganic world to carry out teams of capabilities important to life as we all know it now.