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ARM Institute points robotic inspection for casting and forging mission name

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ARM Institute points robotic inspection for casting and forging mission name

The ARM Institute mentioned its calls function a platform for collaboration and innovation for initiatives going through an absence of funding or engineering roadblocks. | Supply: ARM Institute

The Superior Robotics for Manufacturing, or ARM, Institute yesterday issued its newest mission name. The Pittsburgh-based group is searching for submissions round robotic inspection for casting and forging.

The ARM Institute mentioned it’s searching for initiatives to satisfy the particular wants of the manufacturing business and the U.S. Division of Protection (DoD). Forged and cast elements lie on the coronary heart of essential industrial and protection methods, in response to the institute. They supply an important contribution to warfighter readiness for the U.S.

Nevertheless, legacy platforms characteristic designs and processes that had been largely conceived, outlined, and saved on paper, famous the ARM Institute. A scarcity of obtainable staff exacerbates the problem of manufacturing low-volume however essential forged and cast elements.

The ARM Institute has 4 said targets. They embody empowering U.S. staff to compete with lower-wage staff overseas; creating new jobs for nationwide safety and prosperity; decreasing the technical, operational, and financial boundaries to adopting robotics; and asserting U.S. management in superior robotics for manufacturing.

In March, the group opened a mission name to assist its effort to construct a nationwide repository for synthetic intelligence-based manufacturing assets. It additionally added employer capabilities to RoboticsCareer.org.

The ARM Institute asserted that the dearth of actual, high quality information to coach AI fashions is a key barrier to adoption. To handle this, the institute is working to outline, acquire, and validate information for machine studying and dataset technology.


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ARM Institute forging inspection mission name has two targets

The ARM Institute mentioned its newest mission name facilities on two aims:

  1. Develop, combine, and exhibit an autonomous, scalable, dimensional, and thermal inspection system for high-mix, low-volume casting and/or forging processes
  2. Develop necessities to increase this functionality from guide relocation to an autonomous cellular platform.

The developed system should exhibit the next capabilities in a forging or foundry atmosphere:

  • Conducts fast in-process scans of small, medium, and enormous elements underneath sizzling and ambient temperatures. It should have the ability to establish discrepancies for rework.
  • Conducts detailed dimensional inspection of small, medium, and enormous elements at sizzling and ambient temperatures. It should have the ability to establish discrepancies for rework.

The submission deadline for full proposals is Could 2, whereas the deadline for supporting paperwork is Could 6. The ARM Institute plans to launch last choices and start subaward negotiations round Could 8. The sub-award execution deadline is then on Could 29, whereas the goal mission begin date is on or earlier than Could 30.

The Institute mentioned its mission calls comply with its mission to safe the nation’s future in manufacturing. The calls are open to the general public, however solely ARM Institute members can submit proposals.

Researchers Efficiently Reverse Retinal Harm – NanoApps Medical – Official web site


Blocking the PROX1 protein allowed KAIST researchers to regenerate broken retinas and restore imaginative and prescient in mice.

Imaginative and prescient is among the most necessary human senses, but greater than 300 million individuals all over the world are susceptible to shedding it resulting from varied retinal illnesses. Though current remedies have helped gradual the development of those situations, no efficient remedy has been in a position to restore imaginative and prescient that has already been misplaced, till now. Researchers at KAIST have developed a brand new drug that efficiently restores imaginative and prescient.

On March 30, KAIST introduced {that a} analysis workforce headed by Professor Jin Woo Kim from the Division of Organic Sciences has created a therapy that regenerates retinal nerves to revive imaginative and prescient.

Ph.D. Candidate Museong Kim, Professor Jin Woo Kim, and Dr. Eun Jung Lee
From left, Ph.D. candidate Museong Kim, Professor Jin Woo Kim, and Dr. Eun Jung Lee of KAIST Division of Organic Sciences. Credit score: KAIST Laboratory of Neural Improvement and Regeneration

In experiments utilizing a disease-model mouse, the workforce achieved each retinal regeneration and imaginative and prescient restoration by blocking the PROX1 (prospero homeobox 1) protein, which usually prevents retinal restore. The outcomes have been long-lasting, with results persevering with for greater than six months.

First long-term retinal restore in mammals

This examine marks the primary profitable induction of long-term neural regeneration in mammalian retinas, providing new hope to sufferers with degenerative retinal illnesses who beforehand had no therapy choices.

As the worldwide inhabitants continues to age, the variety of retinal illness sufferers is steadily growing. Nonetheless, no remedies exist to revive broken retinas and imaginative and prescient. The first purpose for that is the mammalian retina’s incapacity to regenerate as soon as broken.

Schematic Diagram of the Mechanism of Retinal Regeneration
Schematic diagram of the mechanism of retinal regeneration by way of inhibition of PROX1 migration. PROX1 protein secreted from retinal broken retinal neurons transfers to Müllerglia and inhibits dedifferentiation into neural progenitor cells and neural regeneration. When PROX1 is captured exterior the cells by an antibody towards PROX1 and its switch to Müllerglia is interfered, dedifferentiation of Müllerglia cells and retinal regeneration processes are resumed, restoring visible operate. Credit score: KAIST Laboratory of Neural Improvement and Regeneration

Research on cold-blooded animals, reminiscent of fish—recognized for his or her strong retinal regeneration—have proven that retinal accidents set off Müller glia cells to dedifferentiate into retinal progenitor cells, which then generate new neurons. Nonetheless, in mammals, this course of is impaired, resulting in everlasting retinal injury.

PROX1 protein recognized as a regeneration blocker

By way of this examine, the analysis workforce recognized the PROX1 protein as a key inhibitor of Müller glia dedifferentiation in mammals. PROX1 is a protein present in neurons of the retina, hippocampus, and spinal twine, the place it suppresses neural stem cell proliferation and promotes differentiation into neurons.

The researchers found that PROX1 accumulates in broken mouse retinal Müller glia, however is absent within the extremely regenerative Müller glia of fish. Moreover, they demonstrated that the PROX1 present in Müller glia will not be synthesized internally however somewhat taken up from surrounding neurons, which fail to degrade and as a substitute secrete the protein.

Results of Anti PROX1 Gene Therapy
Retinal regeneration and visible restoration in a retinitis pigmentosa mannequin mouse by way of Anti-PROX1 gene remedy. After administration of adeno-associated virus expressing PROX1 neutralizing antibodies (AAV2-Anti-PROX1) to the eyes of RP1 retinitis pigmentosa mannequin mice with imaginative and prescient loss, the photoreceptor cell layer of the retina is restored (A) and imaginative and prescient is restored (B). Credit score: KAIST Laboratory of Neural Improvement and Regeneration

Primarily based on this discovering, the workforce developed a way to revive Müller glia’s regenerative skill by eliminating extracellular PROX1 earlier than it reaches these cells.

This method entails utilizing an antibody that binds to PROX1, developed by Celliaz Inc., a biotech startup based by Professor Jin Woo Kim’s analysis lab. When administered to disease-model mouse retinas, this antibody considerably promoted neural regeneration. Moreover, when delivered, the antibody gene to the retinas of retinitis pigmentosa illness mannequin mice, it enabled sustained retinal regeneration and imaginative and prescient restoration for over six months.

The retinal regeneration-inducing remedy is presently being developed by Celliaz Inc. for utility in varied degenerative retinal illnesses that presently lack efficient remedies. The corporate goals to start scientific trials by 2028.

Dr. Eun Jung Lee said, “We’re about to finish the optimization of the PROX1-neutralizing antibody (CLZ001) and transfer to preclinical research earlier than administering it to retinal illness sufferers. Our aim is to supply an answer for sufferers susceptible to blindness who presently lack correct therapy choices.”

Reference: “Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 switch” by Eun Jung Lee, Museong Kim, Sooyeon Park, Ji Hyeon Shim, Hyun-Ju Cho, Jung Ah Park, Kihyun Park, Dongeun Lee, Jeong Hwan Kim, Haeun Jeong, Fumio Matsuzaki, Seon-Younger Kim, Jaehoon Kim, Hanseul Yang, Jeong-Soo Lee and Jin Woo Kim, 25 March 2025, Nature Communications.
DOI: 10.1038/s41467-025-58290-8

This analysis was supported by analysis funds from the Korean Nationwide Analysis Basis (NRF) and the Korea Drug Improvement Basis (KDDF).

Cisco Refresh: The place function meets companion profitability, past Earth Day


At Cisco, sustainability isn’t just a once-a-year dedication – it’s part of how we assist companions of their efforts to make extra sustainable, cost-effective choices daily. Cisco Refresh, considered one of Cisco’s longest-standing initiatives, is one instance of an providing that gives each enterprise and sustainability advantages to clients.

In the present day, Cisco Refresh continues to be an essential a part of Cisco’s efforts to evolve to a round enterprise mannequin. Now in its third decade, Cisco Refresh sells licensed, remanufactured Cisco merchandise at decrease costs than new ones, however with all the identical guarantee and repair choices as them. This extends the helpful life cycle of our merchandise and reduces the necessity for virgin supplies – enabling clients to higher execute on their greenhouse gasoline (GHG) emissions discount and sustainability objectives.

For instance:

  • Prospects who select Cisco Refresh switches or IP telephones can notice a minimum of a 60% discount in embodied carbon emissions in comparison with buying equal new merchandise.

Transitioning to a Round Enterprise Mannequin

Cisco strives to speed up the transition from a conventional linear financial system that extracts sources and finally wastes them, to a round one which finds new makes use of for merchandise and their inputs to reduce waste and optimize useful resource use.

Cisco Refresh is central to this transformation, complementing our portfolio designed with circularity in thoughts, together with versatile cost and subscription fashions, to maximise product life cycle worth.

We focus our efforts in three core areas:

  • Round Design: Embedding sustainability into how we design our merchandise and packaging from the outset.
  • Round Choices: Enabling clients and companions to embrace circularity by applications like Cisco Refresh and Cisco Inexperienced Pay.
  • Recuperate and Redeploy: Recapturing used {hardware} to increase product life by reuse, remanufacturing, and recycling.

 Driving Enterprise Sustainability: The Cisco Circularity Promotion

We wish to allow our clients and companions to learn from Cisco Refresh. The Cisco Circularity Promotion provides Cisco companions and distributors aggressive pricing on licensed remanufactured merchandise, together with present and end-of-sale gadgets, enhancing value financial savings whereas selling round practices.

Since its January 2024 launch, the promotion has:

  • Expanded from 576 to over 1,300 remanufactured (-RF) merchandise.
  • Simplified and standardized pricing and reductions:
    • 55% low cost on Subsequent-Gen Firewall & Community Safety
    • 60% low cost on Enterprise Switching & Wi-fi
    • 65% low cost on Optics
    • 70% low cost on Hyper Converged
    • 75% low cost on Edge Routing and Servers
  • Expanded from the U.S., Canada, Europe and the Center East, to the Asia Pacific area, offering worldwide protection.
  • Acquired 474 new companions, indicating sturdy utilization.
  • Elevated utilization throughout all buyer segments (SMB, Business, Public Sector, Service Supplier, and Enterprise).

Streamlining Enterprise Operations

We prioritize simplicity alongside sustainability. Enhanced visibility and entry to Cisco Refresh stock embody:

  • CCW BOT Integration: Companions can now verify lead occasions and inventory availability for licensed remanufactured tools (famous with an “-RF” suffix) through the CCW BOT (ccwbot@webex.bot). This helps companions keep knowledgeable about any updates to steer occasions, as usually “-RF” merchandise ship quicker than new Cisco merchandise, a key perception for planning and managing orders successfully. Companions (1-Tier and 2-Tier) and Distributors can all entry the CCW BOT.
  • Cisco Refresh Stock Visibility API: This enhanced API gives real-time entry to in-stock remanufactured merchandise which can be able to be ordered now. Companions leveraging this functionality can maximize their Cisco Refresh mix, which might positively influence their margins. Please view the API implementation tips right here.

This Earth Day and daily, Cisco is proud to empower our companions and clients with the instruments to assist lower your expenses, scale back waste, preserve sources, and function extra sustainably.

Should you’re fascinated about studying extra firsthand, Cisco Refresh can be featured within the Goal Pavilion on the upcoming Cisco Reside in San Diego, CA (June 9-12, 2025), so come by and converse to representatives for our group!

To be taught extra about our round financial system transformation, go to our Goal Reporting Hub.

For normal questions on Cisco Refresh, please electronic mail our group at refreshquestions@cisco.com.

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New Type of Darkish Matter May Remedy Many years-Previous Milky Approach Thriller

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Astronomers have lengthy been puzzled by two unusual phenomena on the coronary heart of our galaxy. First, the gasoline within the central molecular zone (CMZ), a dense and chaotic area close to the Milky Approach’s core, seems to be ionized (that means it’s electrically charged as a result of it has misplaced electrons) at a surprisingly excessive charge.

Second, telescopes have detected a mysterious glow of gamma rays with an vitality of 511 kilo-electronvolts (keV) (which corresponds to the vitality of an electron at relaxation).

Apparently, such gamma rays are produced when an electron and its antimatter counterpart—all basic charged particles have antimatter variations of themselves which might be close to equivalent, however with reverse cost—the positron, collide and annihilate in a flash of sunshine.

The causes of each results have remained unclear, regardless of a long time of commentary. However in a brand new research, printed in Bodily Evaluation Letters, my colleagues and I present that each could possibly be linked to one of the elusive elements within the universe: darkish matter. Specifically, we suggest {that a} new type of darkish matter, much less huge than the categories astronomers sometimes search for, could possibly be the wrongdoer.

Hidden Course of

The CMZ spans virtually 700 gentle years and comprises a number of the most dense molecular gasoline within the galaxy. Over time, scientists have discovered that this area is unusually ionized, that means the hydrogen molecules there are being break up into charged particles (electrons and nuclei) at a a lot quicker charge than anticipated.

This could possibly be the results of sources akin to cosmic rays and starlight that bombard the gasoline. Nonetheless, these alone don’t appear to have the ability to account for the noticed ranges.

The opposite thriller, the 511-keV emission, was first noticed within the Seventies, however nonetheless has no clearly recognized supply. A number of candidates have been proposed, together with supernovas, huge stars, black holes, and neutron stars. Nonetheless, none absolutely clarify the sample or depth of the emission.

We requested a easy query: May each phenomena be brought on by the identical hidden course of?

Darkish matter makes up round 85 % of the matter within the universe, however it doesn’t emit or take up gentle. Whereas its gravitational results are clear, scientists don’t but know what it’s manufactured from.

One chance, typically ignored, is that darkish matter particles could possibly be very gentle, with plenty just some million electronvolts, far lighter than a proton, and nonetheless play a cosmic function. These gentle darkish matter candidates are usually known as sub-GeV (giga electronvolts) darkish matter particles.

Such darkish matter particles could work together with their antiparticles. In our work, we studied what would occur if these gentle darkish matter particles are available contact with their very own antiparticles within the galactic heart and annihilate one another, producing electrons and positrons.

Within the dense gasoline of the CMZ, these low-energy particles would shortly lose vitality and ionize the encircling hydrogen molecules very effectively by knocking off their electrons. As a result of the area is so dense, the particles wouldn’t journey far. As an alternative, they might deposit most of their vitality regionally, which matches the noticed ionization profile fairly properly.

Utilizing detailed simulations, we discovered that this easy course of, darkish matter particles annihilating into electrons and positrons, can naturally clarify the ionization charges noticed within the CMZ.

Even higher, the required properties of the darkish matter, akin to its mass and interplay power, don’t battle with any identified constraints from the early universe. Darkish matter of this sort seems to be a critical possibility.

The Positron Puzzle

If darkish matter is creating positrons within the CMZ, these particles will finally decelerate and finally annihilate with electrons within the atmosphere, producing gamma-rays at precisely 511-keV vitality. This would supply a direct hyperlink between the ionization and the mysterious glow.

We discovered that whereas darkish matter can clarify the ionization, it could additionally be capable to replicate some quantity of 511-keV radiation as properly. This putting discovering means that the 2 alerts could doubtlessly originate from the identical supply, gentle darkish matter.

The precise brightness of the 511-keV line depends upon a number of components, together with how effectively positrons type certain states with electrons and the place precisely they annihilate although. These particulars are nonetheless unsure.

A New Solution to Check the Invisible

No matter whether or not the 511-keV emission and CMZ ionization share a typical supply, the ionization charge within the CMZ is rising as a useful new commentary to check darkish matter. Specifically, it gives a method to check fashions involving gentle darkish matter particles, that are troublesome to detect utilizing conventional laboratory experiments.

More details Image of the night sky above Paranal, Chile on 21 July 2007, taken by ESO astronomer Yuri Beletsky. A

Transfer observations of the Milky Approach might assist check theories of darkish matter. ESO/Y. Beletsky, CC BY-SA

In our research, we confirmed that the anticipated ionization profile from darkish matter is remarkably flat throughout the CMZ. That is vital, as a result of the noticed ionization is certainly unfold comparatively evenly.

Level sources such because the black gap on the heart of the galaxy or cosmic ray sources like supernovas (exploding stars) can’t simply clarify this. However a easily distributed darkish matter halo can.

Our findings counsel that the middle of the Milky Approach could provide new clues concerning the basic nature of darkish matter.

Future telescopes with higher decision will be capable to present extra info on the spatial distribution and relationships between the 511-keV line and the CMZ ionization charge. In the meantime, continued observations of the CMZ could assist rule out, or strengthen, the darkish matter rationalization.

Both method, these unusual alerts from the guts of the galaxy remind us that the universe continues to be filled with surprises. Typically, wanting inward, to the dynamic, glowing heart of our personal galaxy, reveals probably the most surprising hints of what lies past.

This text is republished from The Dialog beneath a Artistic Commons license. Learn the authentic article.

Copper-to-optics know-how eyed for next-gen AI networking gear



Broadcom’s demonstration and a follow-up session explored the advantages of additional growing CPC, similar to lowered sign integrity penalties and prolonged attain, by channel modeling and simulations, Broadcom wrote in a weblog in regards to the DesignCon occasion.

“Experimental outcomes confirmed profitable implementation of CPC, demonstrating its potential to handle bandwidth and sign integrity challenges in information facilities, which is essential for AI functions,” Broadcom acknowledged.

Along with the demo, Broadcom and Samtec additionally authored a white paper on CPC that acknowledged: “Co-packaged connectivity (CPC) supplies the chance to omit loss and reflection penalties from the [printed circuit board (PCB)] and the package deal. When excessive pace I/O is cabled from the highest of the package deal superior PCB supplies will not be mandatory. Losses from package deal vertical paths and PCB routing could be transferred to the longer attain of cables,” the authors acknowledged.

“As extremely complicated methods are challenged to scale the variety of I/O and their attain, co- packaged connectivity presents alternative. As we method 224G-PAM4 [which uses optical techniques to support 224 Gigabits per second data rates per optical lane] and above, system loss and dominating noise sources necessitate the necessity to re-consider that which has been restricted at the back of the system architect’s thoughts for years: What if we hooked up to the package deal?”

At OFC, Samtec demonstrated its Si-FlyHD co-packaged cable assemblies and Samtec FlyoverOctal Small Type-factor Pluggable (OSFP) over the Samtec Eye Velocity Hyper Low Skew twinax copper cable. Flyover is Samtec’s proprietary method of addressing sign integrity and attain limitations of routing high-speed indicators by conventional printed circuit boards (PCBs).

This analysis platform incorporates Broadcom’s industry-leading 200G SerDes know-how and Samtec’s co-packaged Flyover know-how. Si-Fly HD CPC gives the {industry}’s highest footprint density and sturdy interconnect which permits 102.4T (512 lanes at 200G) in a 95 x 95 mm chip substrate,” Samtec wrote.