I am making an attempt to implement a JSI Bridge in my React Native iOS app, however I can not get the runtime object from RCTCxxBridge after the RCTJavaScriptDidLoadNotification is triggered (it prints as nil).
import React
import React_RCTAppDelegate
@objc class ReactNativeFactoryManager: NSObject {
// Singleton occasion
@objc static let shared = ReactNativeFactoryManager()
personal let reactNativeFactory: RCTReactNativeFactory
personal let delegate: ReactNativeDelegate
// Non-public initializer to make sure singleton utilization
personal override init() {
delegate = ReactNativeDelegate()
reactNativeFactory = RCTReactNativeFactory(delegate: delegate)
tremendous.init()
}
@objc func getFactory() -> RCTReactNativeFactory {
return reactNativeFactory
}
func setupBridge(launchOptions: [UIApplication.LaunchOptionsKey: Any]?) {
reactNativeFactory.bridge = delegate.createBridge(with: delegate, launchOptions: launchOptions ?? [:])
}
}
What I’ve Tried
I’ve confirmed that the RCTJavaScriptDidLoadNotification notification is triggered accurately.
I can get the RCTCxxBridge object, however its runtime property is nil
I’ve tried getting the bridge object each from notification.userInfo[@"bridge"] and ReactNativeFactoryManager.shared.getFactory().bridge
Setting
React Native model: 0.78
iOS model: 18.2
Xcode model: 16.3
Machine/Simulator: iOS Simulator
Questions
Why cannot I get the runtime object?
Ought to the runtime be initialized by the point the RCTJavaScriptDidLoadNotification is triggered?
Is there one other manner or timing to accurately get the JSI runtime?
I think there may be adjustments in how JSI bridging is initialized or accessed in React Native 0.78. If anybody has encountered comparable points or is aware of the right option to entry the JSI runtime within the newest React Native variations, I’d enormously recognize your assist.
Thanks for any help or ideas!
“We need to make it simpler to construct and handle complicated networks, and a few of that’s taking away plenty of the busy work. The talent set of the community engineer goes to evolve fairly a bit, making it attainable for community engineers to fret much less in regards to the tactical particulars and the busy work and extra on structure and orchestration and determination making,” Beevers says.
Community operations professionals face important challenges with configuration drift, says Shamus McGillicuddy, analysis director for the community administration observe at Enterprise Administration Associates (EMA), and “many corporations attempt to construct automation for config compliance to take care of it.” Nonetheless, recognizing drift is a troublesome problem, particularly for big, multi-vendor networks.
“NetBox Labs is providing an enterprise-grade method to config compliance with its Assurance functionality. It discovers precise configs within the discipline, reviews on which manufacturing configs are out of compliance with the NetBox mannequin and gives workflows to plan for mitigation of these config drifts,” McGillicuddy says. Assurance may assist with enterprise organizations seeking to deploy extra automation of their environments, he says, as a result of it gives higher visibility into community adjustments. The kind of instrument may additionally drive different efficiencies.
“First, it eliminates plenty of handbook toil for engineers who’re tasked with remediating config drift. Second, it doubtlessly replaces some customized automation tooling that may be time-consuming to keep up,” McGillicuddy says.
NetBox Assurance is delivered via NetBox Enterprise or NetBox Cloud, with NetBox Cloud being the extra fashionable business providing. Assurance is a business product that requires both the enterprise or cloud platform to work, and it isn’t accessible by way of NetBox’s open-source model. The enterprise model is an on-premises providing, and the cloud model gives a totally managed answer.
Kong has introduced updates to its AI Gateway, a platform for governance and safety of LLMs and different AI sources.
One of many new options in AI Gateway 3.10 is a RAG Injector to cut back LLM hallucinations by robotically querying the vector database and inserting related information to make sure the LLM is augmenting the outcomes with recognized information sources, the corporate defined.
This improves safety as properly by placing the vector database behind the Kong AI Gateway, and in addition improves developer productiveness by permitting them to deal with issues aside from trying to cut back hallucinations.
One other replace in AI Gateway 3.10 is an computerized personally identifiable info (PII) sanitization plugin to guard over 20 classes of PII throughout 12 completely different languages. It really works with most main AI suppliers, and might run on the international platform degree in order that builders don’t must manually code the sanitization into each software they construct.
In accordance with Kong, different related sanitization choices are sometimes restricted to changing delicate information with a token or eradicating it fully, however this plugin optionally reinserts the sanitized information into the response earlier than it reaches the tip consumer, making certain they can get the information they want with out compromising privateness.
“As synthetic intelligence continues to evolve, organizations should undertake strong AI infrastructure to harness its full potential,” mentioned Marco Palladino, CTO and co-founder of Kong. “With this newest model of AI Gateway, we’re equipping our prospects with the instruments essential to implement Agentic AI securely and successfully, making certain seamless integration with out compromising consumer expertise. Furthermore, we’re serving to remedy among the greatest challenges with LLMs, reminiscent of reducing down on hallucinations and enhancing information safety and governance.”
The brand new take a look at may assist determine which sufferers are most certainly to learn from new Alzheimer’s medicine.
A newly developed blood take a look at for Alzheimer’s illness not solely helps affirm the presence of the situation but in addition supplies details about how far the illness has progressed, in accordance with analysis from Washington College Faculty of Medication in St. Louis and Lund College in Sweden.
Whereas a number of Alzheimer’s blood assessments are already obtainable, together with two based mostly on know-how licensed from Washington College, these present assessments primarily help in diagnosing the illness in individuals displaying cognitive signs. Nonetheless, they don’t reveal how superior the signs are or the extent of cognitive decline brought on by Alzheimer’s dementia. This distinction is essential as a result of present therapies for Alzheimer’s are simplest within the early phases. A dependable, accessible methodology to evaluate illness development may assist docs determine which sufferers are most certainly to learn from remedy and the way aggressively they need to be handled.
The brand new take a look at additionally provides helpful perception into whether or not an individual’s signs are as a consequence of Alzheimer’s or one other underlying situation.
The research was lately printed within the journal Nature Medication.
Within the research, the researchers discovered that ranges of a protein referred to as MTBR-tau243 within the blood precisely replicate the quantity of poisonous accumulation of tau aggregates within the mind and correlate with the severity of Alzheimer’s illness. Analyzing blood ranges of MTBR-tau243 from a bunch of individuals with cognitive decline, the researchers have been in a position to distinguish between individuals with early- or later-stage Alzheimer’s illness and separate each teams of Alzheimer’s sufferers from individuals whose signs have been brought on by one thing apart from Alzheimer’s illness.
“This blood take a look at clearly identifies Alzheimer’s tau tangles, which is our greatest biomarker measure of Alzheimer’s signs and dementia,” stated co-senior creator Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at WashU Medication. “In scientific apply proper now, we don’t have straightforward or accessible measures of Alzheimer’s tangles and dementia, and so a tangle blood take a look at like this could present a significantly better indication if the signs are as a consequence of Alzheimer’s and may assist docs resolve which therapies are greatest for his or her sufferers.”
Monitoring Alzheimer’s illness development from blood
Alzheimer’s illness entails a build-up of a protein, referred to as amyloid, into plaques within the mind, adopted by the event of tangles of tau protein years later. Cognitive signs emerge across the time tau tangles grow to be detectable, and signs worsen because the tangles unfold. The gold customary for staging Alzheimer’s illness is positron emission tomography (PET) mind scans for amyloid plaques and tau tangles. Amyloid scans yield details about the presymptomatic and early symptomatic phases, whereas tau scans are helpful for monitoring later phases of the illness. PET mind scans are extremely correct however costly, time-consuming, and incessantly unavailable outdoors of main analysis facilities, so they aren’t broadly used.
Bateman leads a crew that’s growing blood assessments for Alzheimer’s illness as a extra accessible various to mind scans. They’ve developed two blood assessments that correlate carefully with the quantity of amyloid plaques within the mind. Each are actually utilized by docs to assist prognosis. However till now, there was no blood take a look at that studies on tau ranges within the mind.
In a earlier research, Bateman and colleagues — together with co-first authors Kanta Horie, PhD, a analysis affiliate professor of neurology at WashU Medication, and Gemma Salvadó, PhD, then a postdoctoral researcher at Lund College, and co-senior creator Oskar Hansson, MD, PhD, a professor of neurology at Lund College — confirmed that cerebrospinal fluid ranges of MTBR-tau243 correlate carefully with tau tangles within the mind. Within the present research, the crew prolonged the evaluation to blood. A blood pattern is simpler to gather than cerebrospinal fluid, which is obtained by way of spinal faucet.
WashU Medication researcher Kanta Horie, PhD, locations a pattern in a mass spectrometer that measures protein ranges in blood plasma and different fluids. Horie co-led the event of a blood take a look at for Alzheimer’s illness that diagnoses and phases the illness by utilizing mass spectrometry to measure the extent of a protein referred to as MTBR-tau243. Credit score: Matt Miller
The researchers developed a method to measure MTBR-tau243 ranges in individuals’s blood and in contrast it to the quantity of tau tangles of their brains as measured by mind scans. They piloted the method on information from two cohorts: volunteers at WashU Medication’s Charles F. and Joanne Knight Alzheimer Illness Analysis Heart, which included 108 individuals, and a subset of 55 individuals from the Swedish BioFINDER-2 cohort. To evaluate whether or not the method was generalizable, they validated it in an unbiased dataset consisting of the remaining 739 individuals within the BioFINDER-2 cohort.
The individuals within the two cohorts represented all however essentially the most extreme finish of the spectrum of Alzheimer’s illness, from the presymptomatic stage when mind amyloid ranges are elevated however individuals stay cognitively wholesome, by way of early-stage illness with gentle cognitive impairments, to late symptomatic illness when sufferers exhibit full-blown dementia. For comparability, cognitively wholesome individuals with regular amyloid ranges, and other people with cognitive signs as a consequence of situations apart from Alzheimer’s illness, have been included.
The researchers’ evaluation confirmed that blood MTBR-tau243 ranges mirrored the quantity of tau tangles within the mind with 92% accuracy. MTBR-tau243 ranges within the blood have been regular in asymptomatic individuals no matter amyloid standing, which means that blood MTBR-tau243 ranges don’t change between wholesome individuals and other people within the presymptomatic stage of Alzheimer’s illness with amyloid plaques.
Amongst individuals with cognitive signs as a consequence of Alzheimer’s illness, MTBR-tau243 ranges have been considerably elevated for individuals within the gentle cognitive impairment part of Alzheimer’s illness and far larger — as much as 200 instances — for these within the dementia part. These variations translated into clear separation of individuals in early- and late-stage Alzheimer’s illness. On the identical time, MTBR-tau243 ranges have been regular in individuals with cognitive signs as a consequence of illnesses apart from Alzheimer’s, which means that the take a look at successfully distinguished Alzheimer’s dementia from other forms of dementia.
The know-how underlying the blood take a look at for tau aggregates has been licensed by WashU to C2N Diagnostics, a WashU startup that developed the blood assessments for amyloid. These amyloid assessments incorporate measures of one other type of tau referred to as p-tau217.
“I imagine we are going to use blood-based p-tau217 to find out whether or not a person has Alzheimer’s illness, however MTBR-tau243 can be a extremely helpful complement in each scientific settings and analysis trials,” stated Hansson. “When each of those biomarkers are constructive, the chance that Alzheimer’s is the underlying reason behind an individual’s cognitive signs will increase considerably, in comparison with when solely p-tau217 is irregular. This distinction is essential for choosing essentially the most applicable remedy for every affected person.”
Blood assessments may inform personalised Alzheimer’s remedy
Two Alzheimer’s therapies have been authorized by the Meals and Drug Administration (FDA) to sluggish development of the illness, and each work by decreasing amyloid ranges within the mind. Horie stated the quantity and number of obtainable Alzheimer’s drugs could quickly be increasing, as a number of experimental medicine that concentrate on tau or different features of Alzheimer’s illness are within the pipeline. With blood assessments to diagnose and stage the illness, docs would be capable to tailor therapies to the affected person’s specific illness state.
“We’re about to enter the period of personalised drugs for Alzheimer’s illness,” Horie stated. “For early phases with low tau tangles, anti-amyloid therapies might be extra efficacious than in late phases. However after the onset of dementia with excessive tau tangles, anti-tau remedy or one of many many different experimental approaches could also be simpler. As soon as we have now a clinically obtainable blood take a look at for staging, plus therapies that work at completely different phases of the illness, docs will be capable to optimize their remedy plans for the precise wants of every affected person.”
Reference: “Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s illness” by Kanta Horie, Gemma Salvadó, Rama Okay. Koppisetti, Shorena Janelidze, Nicolas R. Barthélemy, Yingxin He, Chihiro Sato, Brian A. Gordon, Hong Jiang, Tammie L. S. Benzinger, Erik Stomrud, David M. Holtzman, Niklas Mattsson-Carlgren, John C. Morris, Sebastian Palmqvist, Rik Ossenkoppele, Suzanne E. Schindler, Oskar Hansson and Randall J. Bateman, 31 March 2025, Nature Medication. DOI: 10.1038/s41591-025-03617-7
This work was supported by the Charles F. and Joanne Knight Alzheimer Illness Analysis Heart; the Tracy Household SILQ Heart; the Nationwide Institutes of Well being (NIH), grant quantity R01AG070941; the Alzheimer’s Affiliation’s Zenith Award; the Hope Heart for Neurological Problems; and the Division of Neurology at WashU Medication. The Swedish BioFINDER-2 research was supported by the U.S. Nationwide Institute on Ageing, grant quantity R01AG083740, the European Analysis Council, grant quantity ADG-101096455; the Alzheimer’s Affiliation, grant numbers ZEN24-1069572 and SG-23-1061717; the GHR Basis; the Swedish Analysis Council, grant numbers 2022-00775, 2021-02219, and 2018-02052; ERA PerMed, grant quantity ERAPERMED2021-184; the Knut and Alice Wallenberg basis, grant quantity 2022-0231; the Strategic Analysis Space MultiPark (Multidisciplinary Analysis in Parkinson’s illness) at Lund College; the Swedish Alzheimer Basis, grant numbers AF-980907, AF-994229, and AF-994075; the Swedish Mind Basis, grant numbers FO2021-0293, FO2023-0163 and FO2022-0204; the Wallenberg AI, Autonomous Techniques and Software program Program (WASP) and the SciLifeLab and Wallenberg Nationwide Program for Information-Pushed Life Science (DDLS) joint name for analysis initiatives, grant quantity WASP/DDLS22-066; the Parkinson basis of Sweden, grant quantity 1412/22; the Treatment Alzheimer’s fund; the Rönström Household Basis; the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; the Skåne College Hospital Basis, grant quantity 2020-O000028; the Regionalt Forskningsstöd, grant quantity 2022-1259; and the Swedish federal authorities below the ALF settlement, grant numbers 2022-Projekt0080 and 2022-Projekt0107. Gemma Salvadó acquired funding from the European Union’s Horizon 2020 Analysis and Innovation Program below Marie Sklodowska-Curie motion grant settlement quantity 101061836; the Alzheimer’s Affiliation, fellowship quantity AARF-22-972612; the Alzheimerfonden, grant quantity AF-980942; BrightFocus Basis, fellowship quantity A2024007F; Greta och Johan Kocks; and the Strategic Analysis Space MultiPark (Multidisciplinary Analysis in Parkinson’s Illness) at Lund College.
As soon as the unique area of governments and protection companies, Earth Commentary (EO) is now an important software for industries tackling local weather dangers, provide chain administration, and regulatory compliance. As local weather change accelerates and international laws tighten, EO know-how is remodeling how we monitor and reply to environmental challenges.
The EO market has a projected financial worth of over $700B by 2030 and the potential to cut back two gigatons of greenhouse gasoline emissions yearly. The variety of lively EO satellites is anticipated to just about triple within the subsequent decade, pushed largely by industrial operators. This surge in deployment will decrease prices, develop knowledge availability, and gas new purposes as competitors intensifies. Almost 80% of EO’s complete financial affect is forecasted to return from climate- and nature-related use circumstances, with three key outcomes:
Value Avoidance: Helps handle pure hazard dangers, defend infrastructure, and guarantee regulatory compliance to keep away from penalties _
Mitigation: Allows emissions monitoring and local weather variable monitoring, supporting mitigation efforts like GHG discount and carbon seize _
Adaptation: Helps ecosystem monitoring to strengthen biodiversity, habitat conservation, and total ecological well being
Tech Innovation is Enhancing Accessibility and Impression
Slicing-edge applied sciences are enhancing EO’s capabilities and purposes, opening new frontiers in local weather monitoring. For instance, enhanced sensors now supply superior international protection and backbone capturing 2-3 instances extra spectral knowledge than conventional strategies. Expansions in Artificial Aperture Radar (SAR) know-how captures photos by clouds and darkness, enabling steady monitoring for flood detection, deforestation monitoring, and polar ice measurement. The selection in satellite tv for pc sizes additionally expands the scope of use circumstances.
Smaller, more cost effective sensors enhance the supply of public and industrial EO knowledge and scale back reliance on heavy ground-based tools, whereas bigger satellites with superior capabilities are enabling extra advanced devices and better knowledge transmission capacities.
Moreover, knowledge evaluation is being reworked, with AI enabling sooner and extra detailed knowledge evaluation. Superior algorithms course of knowledge as much as 1,000 instances sooner than conventional fashions, permitting AI-powered flood mapping and catastrophe assessments to be performed in minutes somewhat than weeks. Physics-informed local weather fashions, which mix bodily rules with machine studying, present extremely localized local weather forecasting with considerably improved vitality effectivity. Moreover, digital twins, which create digital replicas of Earth’s local weather methods, allow real-time simulation of local weather methods, enhancing decision-making and threat evaluation.
Promising Cleantech Functions
Early adopters embody tech-ready industries reminiscent of insurance coverage, carbon markets, oil & gasoline, and mining, that are utilizing EO for strategic decision-making:
Industries like agriculture, maritime, utilities, provide chain, and transportation are anticipated to seize market share over an extended time interval, in keeping with their propensity to undertake applied sciences later:
Accelerating Adoption
Stricter local weather laws are pushing industries to undertake EO for compliance and sustainability. For instance, the EU Deforestation Regulation (EUDR) incentivizes biodiversity monitoring and deforestation monitoring, and the EU Methane Regulation requires satellite-based leak detection for compliance. The Company Sustainability Reporting Directive (CSRD) mandates local weather threat disclosure for corporations listed on EU-regulated markets, whereas the U.S. SEC Local weather Disclosure Guidelines (2024) require public corporations to report on climate-related dangers and emissions.
Geographically, adoption developments replicate regional wants. North America, Europe, and Australia are embracing EO to mitigate wildfire dangers and adjust to environmental laws. In the meantime, South and Southeast Asia are leveraging EO for infrastructure resilience and energy grid monitoring. There’s additionally an rising development of island nations in Asia and Africa prioritizing local weather monitoring and protection purposes.
Overcoming Challenges
Regardless of its potential, the excessive prices and restricted entry to high-resolution EO datasets could be significantly prohibitive for early-stage innovators. Nevertheless, open-data initiatives from tech giants like Google and Amazon are serving to to extend accessibility and scale back these boundaries. Technical experience additionally stays a bottleneck for a lot of corporations, as EO requires specialised information in satellite tv for pc engineering, knowledge tasking, and evaluation. Moreover, cross-border knowledge sharing raises considerations about knowledge privateness and nationwide safety as delicate data could be captured, making the know-how topic to authorized and geopolitical scrutiny.
A Sizzling Marketplace for Innovation and Funding
Current acquisitions exhibit rising confidence in EO start-ups and sign a sturdy exit market. Notable offers embody Neo Area Groupbuying UP42, EarthDaily Analytics buying Descartes Labs, Fugro buying EOMAP, and Nuviewbuying Astraea. This development means that established gamers see strategic worth in buying and integrating progressive EO capabilities somewhat than growing them in-house.
Whereas local weather funding cuts within the U.S. pose challenges, EO innovators can nonetheless discover stability by addressing dual-use purposes, balancing environmental monitoring with protection capabilities. Geopolitical dangers and growing funding in surveillance will proceed to maintain the EO market, offering long-term alternatives for corporations working on the intersection of local weather and safety.
The way forward for EO lies within the integration of superior computing, AI, and satellite tv for pc know-how. Rising improvements reminiscent of edge computing and digital twins promise sooner, extra actionable insights. Because the trade evolves, corporations that may navigate the trade-offs between protection, decision, and persistence whereas delivering high-value options will lead the subsequent wave of EO-driven local weather innovation.
